Super CitriMax® is the active ingredient in Diet Water®
Results of the double-blind placebo-controlled study showed that at the dosage level given, Super CitriMax significantly:
· Curbs appetite and reduces food intake*
· Inhibits fat synthesis and increases fat “burning”*
· Reduces body weight and decreases (3-times greater than diet and excercise alone)*
· Body Mass Index (an indicator of healthy body weight)*
· Maintains healthy cholesterol levels*
The Super CitriMax Study Protocol
The randomized, double-blind, placebo-controlled human clinical trial was conducted using Super CitriMax, a standardized calcium/potassium (-) hydroxycitric acid (HCA) extract containing 60% HCA (patent-pending). Approximately 90 moderately overweight human subjects were enrolled in the study. Subjects were placed on a daily diet of 2,000 kcal. Food was prepared and delivered to the subjects, and food intake was strictly supervised by trained dieticians. Subjects also underwent a 30 minute walking exercise program five days a week, which was supervised by a trained exercise specialist. The subjects were randomly divided into two groups. The first group was given a placebo and the second group was given a daily dose of Super CitriMax (4,666 mgs providing 2,800 mgs HCA) in three equally divided doses, 30-60 minutes before breakfast, lunch and dinner for eight weeks. Changes in body weight, lipid profile (triglycerides, LDL, HDL and total cholesterol), serum serotonin levels (a mechanism of appetite control and eating behavior), Body Mass Index (an indicator of healthy body weight), fat metabolites (malondialdehyde, formaldehyde, acetaldehyde and acetone) and appetite control (food consumption) were assessed.1,2
Body Mass Index (BMI)
BMI is frequently used by clinicians to evaluate the “normalcy” of one’s body weight. BMI has a higher association with body fat than body weight alone. A high BMI is associated with increased risk of cardiovascular disease (including hypertension), diabetes and kidney disease.8 Super CitriMax significantly reduces BMI in the body.1,2
Serotonin and Appetite Control
Appetite suppression of HCA is thought to result from increased glycogen production and concomitant stimulation of glucoreceptors in the liver, which sends signals of satiety to the brain. However, recent clinical and pre-clinical studies show that Super CitriMax increases levels of serotonin (5-HT), a vital neurotransmitter involved in a wide range of behavioral functions in the body, including mood, sleep and appetite control.9 Studies show that serotonin affects eating behavior and body weight. Increased plasma levels of serotonin are associated with decreased food intake, reduced weight gain and increased energy expenditure.10 Super CitriMax significantly inhibits serotonin re-uptake and increases serum serotonin levels in the body.1,2,6,7 Another benefit of increasing serotonin levels may be in addressing many of the emotional issues overweight people face, including binge-eating and depression.
Fat Metabolites
Fat metabolites are products of fat degradation. Following exercise or other fat oxidation (burning) processes, fat tissue breaks down into small molecular components, including malondialdehyde, formaldehyde, acetaldehyde and acetone.11 Increased urinary levels of fat metabolites indicate increased fat degradation or “burning.” Super CitriMax™ significantly increases fat burning as indicated by increased output of urinary fat metabolites.1,2
Proven Bioavailability
Previous human clinical studies conduced at the University of California, Berkeley, show that Super CitriMax’s highly soluble and bioavailable calcium/potassium-HCA complexis absorbed and detectable in the blood stream for up to 9 hours following administration, with peak concentrations at 2 hours. Taken in combination with a full meal, absorption is significantly reduced.3
“Clinical Strength” Dosage
Early animals studies by Hoffmann-La Roche and others indicate that higher levels of HCA than those typically recommended in dietary supplements for humans are required to produce optimum results, and that divided doses taken at least twice a day are more effective than a single dose taken once a day.4,5 Levels of HCA used in the Super CitriMax clinical study were determined by extrapolation of optimal micromolar concentrations of HCA required to evoke peak levels of serotonin release in rat brain cortex employing the following formula:6,7 300 M (optimal HCA concentration in 15 ml) = 4.16 mg/ml HCA 4.16 mg/ml x 3,400 ml (total plasma level of 85 kg human) = 14,144 mg 14,144 mg 5-fold faster metabolism in rats than in humans = 2,828 mg
Look for the Logo on the Label
Subsequently, 2,800 mgs of HCA per day in three divided doses was used in the Super CitriMax® clinical study. For convenience purposes, however, the dosage has been established at 2,700 mgs per day, which allows administration of three 500 mg Super CitriMax capsules (providing 300 mgs HCA per capsule), 3-times per day taken 30-60 minutes before meals (3 caps x 300 mgs HCA/cap x 3-times/day = 2,700 mg HCA/day) (see Super CitriMax Clinical Strength Labeling Guidelines).
Source: Interhealth
2nd Confirming Study: Interhealth
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to cure, mitigate, treat or prevent any disease.
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